insulysin EC#: 3.4.24.56; ChemWhat Code: 1381049
| Product Name | insulysin |
| Example Structure |  |
| Synonyms | ADE, amyloid degrading enzyme, EC 3.4.22.11, EC 3.4.99.10, EC 3.4.99.45, gamma-endorphin-generating enzyme, IDE, insulin degrading enzyme, Insulin protease, Insulin proteinase, Insulin-degrading enzyme, Insulin-degrading neutral proteinase, Insulin-glucagon protease, Insulin-specific protease, Insulinase, Insulysin, Metalloinsulinase, More |
| EC Number | 3.4.24.56 |
| CAS Registry Number | 9013-83-6 |
| Comments | A 110 kDa cytosolic enzyme, known from mammals and the fruit fly,?Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as?N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family). Formerly EC?3.4.22.11, EC?3.4.99.10?and EC?3.4.99.45. |
| Cofactor | Zn2+ |
| History | |
| Reactions | Degradation of insulin, glucagon and other polypeptides. No action on proteins. |
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