interstitial collagenase EC#: 3.4.24.7; ChemWhat Code: 1380945
| Product Name | interstitial collagenase |
| Example Structure |  |
| Synonyms | azocollase, collagen peptidase, collagen protease, collagenase, collagenase 1, collagenase A, collagenase MMP-1, collagenase-1, EC 3.4.99.5, ect-MMP-14, Fibroblast collagenase, HSFC, kollaza, macrophage matrix metalloproteinase, matrix metalloproteinase 1, matrix metalloproteinase-1, matrix metalloproteinase-18, matrix-metalloproteinase-1, membrane-type 1-MMP, metallocollagenase, metalloproteinase-1, MMP-1, MMP-12, MMP-14, MMP-1A, mmp1, MT1-MMP, Myocardial collagenase, nucleolysin, soycollagestin, TC1, tumor collagenase, vertebrate collagenase |
| EC Number | 3.4.24.7 |
| CAS Registry Number | 9001/12/1 |
| Comments | The enzyme takes its name from substrates of the interstitial collagen group – types I, II and III, all of which are cleaved in the helical domain. However, ¦Á-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family?M10. |
| Cofactor | Zn2+ |
| History | |
| Reactions | Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1′ is a hydrophobic residue. |
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