kallikrein 13 EC#: 3.4.21.119; ChemWhat Code: 1380670
| Product Name | kallikrein 13 |
| Example Structure |  |
| Synonyms | GK-13, glandular kallikrein 13, glandular kallikrein K13, hK13, K13, kallikrein-related peptidase 13, KLK13, MGK-13, mK13, More, PRECE, prorenin converting enzyme, prorenin-converting enzyme, S01.306, tissue kallikrein |
| EC Number | 3.4.21.119 |
| CAS Registry Number | |
| Comments | The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1¦Â (pro-IL-1¦Â) in mouse submandibular gland to form IL-1¦Â [4]. Belongs in peptidase family?S1A. |
| Cofactor | |
| History | |
| Reactions | Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin. |
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