L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] EC#: 1.1.1.375; ChemWhat Code: 1373499
| Product Name | L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] |
| Example Structure | ![Example Structure of L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] EC#: 1.1.1.375](/wp-content/uploads/enzyme-structure/1.1.1.375.jpg) |
| Synonyms | |
| EC Number | 1.1.1.375 |
| CAS Registry Number | |
| Comments | The enzyme from the archaeon Methanocaldococcus jannaschii catalyses the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-sulfolactate has the same stereochemical configuration as (2S)-2-hydroxycarboxylates) [1]. The enzyme can use both NADH and NADPH, although activity is higher with NADPH [1-3]. The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP+ [1]. The same organism also possesses an NAD+-specific enzyme with similar activity, cf. EC 1.1.1.337, L-2-hydroxycarboxylate dehydrogenase (NAD+). |
| Cofactor | |
| History | |
| Reactions | A (2S)-2-hydroxycarboxylate + NAD(P)(+) = a 2-oxocarboxylate + NAD(P)H. |
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