L-ornithine N5-monooxygenase [NAD(P)H] EC#: 1.14.13.196; ChemWhat Code: 1375436

Product Name L-ornithine N5-monooxygenase [NAD(P)H]
Example Structure Example Structure of L-ornithine N5-monooxygenase [NAD(P)H] EC#: 1.14.13.196
Synonyms abachelin monooxygenase, AfSidA, AMO, SidA, siderophore A
EC Number 1.14.13.196
CAS Registry Number
Comments A flavoprotein (FAD). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyses a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria sp. 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics. Activity of the fungal enzyme is higher with NADPH, due to the fact that following the reduction of the flavin, NADP+ (but not NAD+) stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the substrate [3]. cf. EC 1.14.13.195, L-ornithine N5-monooxygenase (NADPH).
Cofactor FAD
History
Reactions L-ornithine + NAD(P)H + O(2) = N(5)-hydroxy-L-ornithine + NAD(P)(+) + H(2)O.

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