| Synonyms |
bsLSD type 1, cSDH, Dehydratase, L-serine, EC 4.2.1.13, GSU0486, HSDH, L-Hydroxy amino acid dehydratase, L-SD, L-SD1, L-SD2, L-serine ammonia-lyase, L-Serine deaminase, L-serine deaminase 2, L-serine dehydratase, L-serine dehydratase 1, L-serine dehydratase 2, L-threonine deaminase, L-threonine dehydratase, lpLSD, lpLSD type 2, More, MSMEG_3532, PH0054, SD, SdaA, SdaB, SDH, SDH-like-1, SDH1, SDH2, SdhA, SerDH, Serine deaminase, Serine dehydratase, serine dehydratase like-1, tdcB, TdcG |
| Comments |
Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead [6]. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme’s original classification as EC?4.2.1.13,?L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC?3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC?4.3.1.19, threonine ammonia-lyase, from a number of sources. |
