leishmanolysin EC#: 3.4.24.36; ChemWhat Code: 1381016
| Product Name | leishmanolysin |
| Example Structure |  |
| Synonyms | 66 kDa surface metallopeptidase, Cell surface protease, Glycoprotein gp63, gp63, GP63 protein, GP63 surface metalloprotease, Leishmania metalloproteinase, Leishmania surface metalloprotease, leishmanolysin-like molecule, Major surface glycoprotein, major surface protease, major surface-metalloprotease, MSP, Promastigote surface endopeptidase, Promastigote surface protease, protective surface protease, Surface acid proteinase, surface leishmanolysin-like molecule, surface protease GP63, surface protein GP63, surface proteinase GP63 |
| EC Number | 3.4.24.36 |
| CAS Registry Number | 161052-06-8 |
| Comments | A membrane-bound glycoprotein found on the promastigote of various species of?Leishmania?protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100©àVal bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family?M8. |
| Cofactor | Zn2+;Ca2+ |
| History | |
| Reactions | Preference for hydrophobic residues at P1 and P1′ and basic residues at P2′ and P3′. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-. |
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