| Product Name |
low-specificity L-threonine aldolase |
| Example Structure |
 |
| Synonyms |
GLY1, GlyA, L-TA, L-threonine aldolase, low specificity L-TA, low specificity threonine aldolase, Low-specificity L-threonine aldolase, LTA, LtaE, serine hydroxy-methyl transferase, SHMT, threonine aldolase |
| EC Number |
4.1.2.48 |
| CAS Registry Number |
|
| Comments |
Requires pyridoxal phosphate. The low-specificity?L-threonine aldolase can act on both?L-threonine and?L-allo-threonine [1,2]. The enzyme from?Escherichia coli?can also act on?L-threo-phenylserine and?L-erythro-phenylserine [4]. The enzyme can also catalyse the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis [3]. Different from EC?4.1.2.5,?L-threonine aldolase, and EC?4.1.2.49,?L-allo-threonine aldolase. |
| Cofactor |
pyridoxal 5′-phosphate |
| History |
|
| Reactions |
(1) L-threonine = glycine + acetaldehyde. (2) L-allo-threonine = glycine + acetaldehyde. |
