macrophage elastase EC#: 3.4.24.65; ChemWhat Code: 1381062
| Product Name | macrophage elastase |
| Example Structure |  |
| Synonyms | HME, hMMP-12, human macrophage elastase, Human macrophage metalloelastase, human metalloelastase, Macrophage elastase, macrophage matrix metalloproteinase, macrophage metalloelastase, matrix metalloproteinase 12, Matrix metalloproteinase-12, ME, Metalloelastase, MME, MMP-12, MMP12, More, mouse macrophage metalloelastase, rHME |
| EC Number | 3.4.24.65 |
| CAS Registry Number | 9004/6/2 |
| Comments | This enzyme is synthesized as a proenzyme of 53 kDa that is converted to an active form of 22 kDa. cDNA sequences have been obtained for the mouse [3] and human [4] enzymes. In peptidase family?M10?(interstitial collagenase family). |
| Cofactor | Zn2+;Ca2+ |
| History | |
| Reactions | Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin. |
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