malonyl-CoA reductase (malonate semialdehyde-forming) EC#: 1.2.1.75; ChemWhat Code: 1373834
| Product Name | malonyl-CoA reductase (malonate semialdehyde-forming) |
| Example Structure |  |
| Synonyms | malonate-semialdehyde dehydrogenase, malonyl CoA reductase (malonate semialdehyde-forming), malonyl-CoA reductase, MCR |
| EC Number | 1.2.1.75 |
| CAS Registry Number | |
| Comments | Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropionate and the 3-hydroxypropionate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298, 3-hydroxypropionate dehydrogenase (NADP+) [4]. |
| Cofactor | Mg2+ |
| History | |
| Reactions | Malonate semialdehyde + CoA + NADP(+) = malonyl-CoA + Nadph. |
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