matrilysin EC#: 3.4.24.23; ChemWhat Code: 1380983
| Product Name | matrilysin |
| Example Structure |  |
| Synonyms | cyclic matrix metalloproteinase, human matrix metalloproteinase 7, matrilysin, matrilysin 1, matrilysin-1, Matrin, matrix metallopeptidase 7, matrix metalloprotease-7, Matrix metalloproteinase 7, Matrix metalloproteinase pump 1, Matrix metalloproteinase-7, matrix-metalloproteinase-7, metalloproteinase-7, MMP, MMP 7, MMP-7, MMP7, More, Proteinase, metallo-, pump-1, Proteinase, PUMP-1, PUMP, PUMP-1, Pump-1 protease, Putative (or punctuated) metalloproteinase-1, Putative metalloproteinase, Uterine metalloendopeptidase, Uterine metalloproteinase |
| EC Number | 3.4.24.23 |
| CAS Registry Number | 141256-52-2 |
| Comments | Found in rat uterus; at 19 kDa, the smallest member of peptidase family?M10?(interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll. |
| Cofactor | Zn2+;Ca2+ |
| History | |
| Reactions | Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, ii, iv, v. Cleaves gelatin chain alpha-2(I) > alpha-1(I). |
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