memapsin 1 EC#: 3.4.23.45; ChemWhat Code: 1380917
| Product Name | memapsin 1 |
| Example Structure |  |
| Synonyms | aspartic protease BACE2, BACE 2, BACE-1 homologue, BACE-2, BACE2, beta site APP cleaving enzyme, beta-secretase, beta-secretase 2, beta-site Alzheimer’s amyloid precurser protein cleaving enzyme 2, beta-site amyloid precursor protein cleaving enzyme 2, beta-site amyloid precursor protein-cleaving enzyme 2, beta-site APP cleaving enzyme, beta-site APP-cleaving enzyme 2, down region aspartic protease, DRAP, memapsin-1, memapsin1, membrane aspartic protease of the pepsin family, More, protease ASP1, theta-secretase |
| EC Number | 3.4.23.45 |
| CAS Registry Number | |
| Comments | Can cleave ¦Â-amyloid precursor protein to form the amyloidogenic ¦Â-peptide that is implicated in the pathology of Alzheimer’s disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain. |
| Cofactor | |
| History | |
| Reactions | Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer’s amyloid precursor protein. |
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