meprin A EC#: 3.4.24.18; ChemWhat Code: 1380972
| Product Name | meprin A |
| Example Structure |  |
| Synonyms | E-24.18, EC 3.4.24.11, Endopeptidase-2, M12.002, Meprin, meprin A, meprin A metalloprotease, meprin A metalloproteinase, meprin alpha, meprin alpha1, meprin alpha2, meprin beta, meprin metalloprotease, meprin metalloproteinase, Meprin-a, meprin-alpha, metalloprotease meprin A, More, mouse meprin alpha, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA peptide hydrolase, PABA-peptide hydrolase, PPH, PPH alpha, PPH beta, procollagen proteinase |
| EC Number | 3.4.24.18 |
| CAS Registry Number | 148938-24-3 |
| Comments | A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts. Differences from neprilysin (EC?3.4.24.11) include insensitivity to phosphoramidon and thiorphan. PABA-peptide hydrolase is a very similar enzyme found in human intestinal microvilli [4]. In peptidase family?M12?(astacin family). Formerly included in EC?3.4.24.11. |
| Cofactor | Zn2+ |
| History | |
| Reactions | Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues. |
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