meprin B EC#: 3.4.24.63; ChemWhat Code: 1381058
| Product Name | meprin B |
| Example Structure |  |
| Synonyms | mephrin beta, Meprin b, meprin B metalloprotease, meprin beta, meprin beta metalloproteinase, meprin metalloprotease, meprin metalloproteinase, meprin metalloproteinase beta, meprin-beta, meprinbeta, metalloprotease meprin, metalloprotease meprin B, More, mouse meprin beta, procollagen proteinase |
| EC Number | 3.4.24.63 |
| CAS Registry Number | 150679-52-0 |
| Comments | A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin?b?subunits (in contrast to meprin A, which contains both?a?and?b?subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family?M12?(astacin family). |
| Cofactor | Zn2+ |
| History | |
| Reactions | Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and 19-Cys-|-Gly-20 bonds in insulin B chain. |
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