methionine gamma-lyase EC#: 4.4.1.11; ChemWhat Code: 1382913

Product Name methionine gamma-lyase
Example Structure Example Structure of methionine gamma-lyase EC#: 4.4.1.11
Synonyms CalE6, EhMGL1, EhMGL2, fer1MgL2, Fn1419, L-methionase, L-methioninase, L-methionine gamma-lyase, L-methionine gamma-lyase 1, L-methionine-alpha-deamino-gamma-mercaptomethane lyase, L-methionine-alpha-deamino-gamma-mercaptomethane-lyase, L-methionine-gamma-lyase, lyase, methionine, MdeA, MegL, METase, methioninase, methionine alpha,gamma-lyase, methionine dethiomethylase, methionine gamma-lyase, methionine lyase, methionine-gamma-lyase, MGL, MGL1, MGL2, rMETase, sav7062, TvMGL1, TvMGL2, YtjE
EC Number 4.4.1.11
CAS Registry Number 42616-25-1
Comments A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC?3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme is involved in?L-methionine catabolism.
Cofactor pyridoxal 5′-phosphate
History
Reactions L-methionine + H(2)O = methanethiol + NH(3) + 2-oxobutanoate.

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