methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing) EC#: 2.1.1.74; ChemWhat Code: 1376239

Product Name methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing)
Example Structure Example Structure of methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing) EC#: 2.1.1.74
Synonyms EC2.1.2.12, FDRTS, folate-dependent ribothymidyl synthase, folate-dependent tRNA methyltransferase, folate/FAD-dependent tRNA T54 methyltransferase, methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase,, TRMFO, tRNA (m5U54)-methyltransferase, tRNA:m5U-54 MTase
EC Number 2.1.1.74
CAS Registry Number 74665-78-4
Comments A flavoprotein (FAD). Up to 25% of the bases in mature tRNA are post-translationally modified or hypermodified. One almost universal post-translational modification is the conversion of U54 into ribothymidine in the T¦·C loop, and this modification is found in most species studied to date [2]. Unlike this enzyme, which uses 5,10-methylenetetrahydrofolate and NAD(P)H to supply the atoms for methylation of U54, EC 2.1.1.35, tRNA (uracil54-C5)-methyltransferase, uses S-adenosyl-L-methionine.
Cofactor
History
Reactions 5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH(2) = tetrahydrofolate + 5-methyluracil(54) in tRNA + Fad.

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