(methylsulfanyl)alkanaldoxime N-monooxygenase EC#: 1.14.14.43; ChemWhat Code: 1375551

Product Name (methylsulfanyl)alkanaldoxime N-monooxygenase
Example Structure Example Structure of (methylsulfanyl)alkanaldoxime N-monooxygenase EC#: 1.14.14.43
Synonyms (methylthio)alkanaldoxime N-monooxygenase, CYP83A1, CYP83A1.1, CYP83B1, cytochrome P450 CYP83A1, cytochrome P450 monooxygenase 83A1-2
EC Number 1.14.14.43
CAS Registry Number
Comments This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of glucosinolates in plants. The enzyme catalyses an N-hydroxylation of the E isomer of n-(methylsulfanyl)aldoximes, forming an aci-nitro intermediate that reacts non-enzymically with glutathione to produce an N-alkyl-thiohydroximate adduct, the committed precursor of glucosinolates. In the absence of a thiol compound, the enzyme is suicidal, probably due to interaction of the reactive aci-nitro intermediate with active site residues.
Cofactor heme-thiolate
History
Reactions An (E)-omega-(methylthio)alkanal oxime + O(2) + glutathione + [reduced NADPH–hemoprotein reductase] = an (E)-1-(glutathione-S-yl)-omega- (methylthio)-alkylhydroximate + 2 H(2)O + [oxidized NADPH–hemoprotein reductase].

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