The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. Two forms are known – MAM1 catalyses only only the first two rounds of methionine chain elongation, while MAM3 catalyses all six cycles, up to formation of L-hexahomomethionine.
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An omega-(methylthio)-2-oxoalkanoate + acetyl-CoA + H(2)O = a 2-(omega- methylthio)alkylmalate + CoA.
