methylxanthine N1-demethylase EC#: 1.14.13.178; ChemWhat Code: 1375413
| Product Name | methylxanthine N1-demethylase |
| Example Structure |  |
| Synonyms | ndmA, P450-d |
| EC Number | 1.14.13.178 |
| CAS Registry Number | |
| Comments | A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH [2]. Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines. |
| Cofactor | Fe cation |
| History | |
| Reactions | (1) Caffeine + O(2) + NAD(P)H = theobromine + NAD(P)(+) + H(2)O + formaldehyde. (2) Theophylline + O(2) + NAD(P)H = 3-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde. (3) Paraxanthine + O(2) + NAD(P)H = 7-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde. |
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