methylxanthine N3-demethylase EC#: 1.14.13.179; ChemWhat Code: 1375414
| Product Name | methylxanthine N3-demethylase |
| Example Structure |  |
| Synonyms | ndmB |
| EC Number | 1.14.13.179 |
| CAS Registry Number | |
| Comments | A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, methylxanthine N1-demethylase, and has higher activity with NADH than with NADPH [1]. Also demethylates caffeine and theophylline with lower efficiency. Forms part of the degradation pathway of methylxanthines. |
| Cofactor | Fe cation |
| History | |
| Reactions | (1) Theobromine + O(2) + NAD(P)H = 7-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde. (2) 3-methylxanthine + O(2) + NAD(P)H = xanthine + NAD(P)(+) + H(2)O + formaldehyde. |
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