Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC?2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon?Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC?2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.
Cofactor
History
Reactions
Atp + (R)-mevalonate = adp + (R)-3-phosphomevalonate.