| Synonyms |
120 kDa collagenase, Achromobacter iophagus collagenase, aspergillopeptidase C, azocollase, bacterial collagenase, CCA, ChC, clostridial collagenase A, clostridiopeptidase A, clostridiopeptidase I, clostridiopeptidase II, Clostridium histolyticum collagenase, ColG, ColH, collagen peptidase, collagen protease, collagenase A, collagenase G, collagenase H, collagenase I, collagenase MMP-1, collagenase T, ColT, EC 3.4.4.19, EC 3.4.99.5, kollaza, matirx metalloproteinase-18, matrix metalloproteinase-1, metallocollagenase, metalloproteinase-1, MMP-1, More, nucleolysin, peptidase, clostridio-, A, proteinase, Clostridium histolyticum, A, soycollagestin, thermophilic collagenolytic protease |
| Comments |
Six species of metalloendopeptidase acting on native collagen can be isolated from the medium of?Clostridium histolyticum. Class I has forms ¦Á (68 kDa), ¦Â (115 kDa) and ¦Ã (79 kDa); class II has ¦Ä (100 kDa), ¦Å (110 kDa) and ¦Æ (125 kDa). The two classes are immunologically crossreactive, but have significantly different sequences, and different specificities such that their actions on collagen are complementary. The enzymes also act as peptidyl-tripeptidases. Variants of the enzyme have been purified from?Bacillus cereus?[10],?Empedobacter collagenolyticum?[4],?Pseudomonas marinoglutinosa?[1], and species of?Vibrio,?Vibrio?B-30 (ATCC 21250) [2] and?V. alginolyticus?(previously?Achromobacter iophagus) [3,8]. Also known from?Streptomyces?sp. [9]. The?Vibrio?enzyme is the type example of peptidase family?M9. Formerly EC?3.4.99.5, EC?3.4.4.19?and EC?3.4.24.8. |
