| Synonyms |
E1-b’, EC 3.3.2.3, Eha, EHb, EPHX 1, EPHX1, JH epoxide hydrolase, JHEH, juvenile hormone epoxide hydrolase, mEH, mEH-like protein, mEH1, mEPHX, microsomal epoxide hydrolase-like protein, microsomal xenobiotic epoxide hydrolase, More, PNSO hydrolase, SEH, styrene-epoxide hydrolase, Tcjheh-r1, Tcjheh-r3, XEHase, xenobiotic epoxide hydrolase |
| Comments |
This is a key hepatic enzyme that catalyses the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols. The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the corresponding?trans-dihydrodiols. The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate. Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC?3.3.2.6?(leukotriene-A4?hydrolase), EC?3.3.2.7?(hepoxilin-epoxide hydrolase), EC?3.3.2.9?(microsomal epoxide hydrolase), EC?3.3.2.10?(soluble epoxide hydrolase) and EC?3.3.2.11?(cholesterol-5,6-oxide hydrolase). |
