| Product Name |
molybdenum cofactor sulfurtransferase |
| Example Structure |
 |
| Synonyms |
ABA3, cysteine desulfurase, LOS5, LOS5/ABA3, MCSU, molybdenum cofactor sulfurase, molybdenum cofactor sulphurase, molybdenum-cofactor sulfurase |
| EC Number |
2.8.1.9 |
| CAS Registry Number |
|
| Comments |
Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC?2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein. |
| Cofactor |
pyridoxal 5′-phosphate |
| History |
|
| Reactions |
Molybdenum cofactor + L-cysteine + reduced acceptor + 2 H(+) = thio- molybdenum cofactor + L-alanine + H(2)O + oxidized acceptor. |
