mRNA N6-methyladenine demethylase EC#: 1.14.11.53; ChemWhat Code: 1375146
| Product Name | mRNA N6-methyladenine demethylase |
| Example Structure |  |
| Synonyms | AlkB homolog 5, ALKBH5, ALKBH5 demethylase, fat mass and obesity-associated protein, FTO, m6A mRNA demethylase, m6A RNA demethylase, m6A-RNA demethylase, N6-methyladenosine demethylase, RNA N6-methyladenine demethylase |
| EC Number | 1.14.11.53 |
| CAS Registry Number | |
| Comments | Contains iron(II). Catalyses oxidative demethylation of mRNA N6-methyladenine. The FTO enzyme from human can also demethylate N3-methylthymine from single stranded DNA and N3-methyluridine from single stranded RNA [1,2] with low activity [3]. |
| Cofactor | Fe3+ |
| History | |
| Reactions | N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2). |
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