mycocerosate synthase EC#: 2.3.1.111; ChemWhat Code: 1376893
| Product Name | mycocerosate synthase |
| Example Structure |  |
| Synonyms | mycocerosic acid synthase |
| EC Number | 2.3.1.111 |
| CAS Registry Number | 95229-19-9 |
| Comments | The enzyme, characterized from mycobacteria, is loaded with a long-chain acyl moiety by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, and elongates it by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the product remains bound and requires additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo. |
| Cofactor | |
| History | |
| Reactions | (1) A long-chain acyl-[mycocerosic acid synthase] + 3 methylmalonyl-CoA + 6 Nadph = a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CoA + 3 CO(2) + 6 NADP(+) + 3 H(2)O. (2) A long-chain acyl-[mycocerosate synthase] + 4 methylmalonyl-CoA + 8 Nadph = a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CoA + 4 CO(2) + 8 NADP(+) + 4 H(2)O. |
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