mycolipanoate synthase EC#: 2.3.1.252; ChemWhat Code: 1377084
Product Name | mycolipanoate synthase |
Example Structure | |
Synonyms | Msl3, Pks2, pks3, polyketide beta-ketoacyl synthase |
EC Number | 2.3.1.252 |
CAS Registry Number | |
Comments | This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyl-tetracosanoate (C27-mycolipanoate). Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal. |
Cofactor | |
History | |
Reactions | A long-chain acyl-CoA + 3 (R)-methylmalonyl-CoA + 6 nadph + holo- [mycolipanoate synthase] = mycolipanoyl-[mycolipanoate synthase] + 4 CoA + 3 CO(2) + 6 NADP(+) + 3 H(2)O. |
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