From?Streptomyces griseus,?S. naraensis, and?S. cacaoi. Specificity similar to that of thermolysin, but much more sensitive to inhibition by mercaptoacetyl-Phe-Leu. Little structural similarity to other bacterial metalloendopeptidases. Type example of peptidase family?M5. Formerly included in EC?3.4.24.4.
Cofactor
Zn2+
History
Reactions
Preferential cleavage of bonds with hydrophobic residues in P1′.