N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase EC#: 2.4.1.244; ChemWhat Code: 1377553
| Product Name | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase |
| Example Structure |  |
| Synonyms | B4GALNT3, beta 1,4-N-acetylgalactosaminyltransferase-A, beta1,4-N-acetylgalactosaminyltransferase, beta1,4-N-acetylgalactosaminyltransferase II, beta1,4-N-acetylgalactosaminyltransferase III, beta1,4-N-acetylgalactosaminyltransferase IV, beta1,4-N-acetylgalactosaminyltransferase-III, beta1,4-N-acetylgalactosaminyltransferases, beta4GalNAc-T3, beta4GalNAc-T4, beta4GalNAcT, beta4GalNAcT-II, beta4GalNAcTA, beta4GalNAcTB, N,N’-diacetyllactosediamine synthase, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2 |
| EC Number | 2.4.1.244 |
| CAS Registry Number | |
| Comments | The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-¦Â-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-¦Â-D-galactosaminyl-(1¡ú4)-N-acetyl-¦Â-D-glucosaminyl group. |
| Cofactor | |
| History | |
| Reactions | UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = Udp + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group. |
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