N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase EC#: 2.4.1.226; ChemWhat Code: 1377530
| Product Name | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase |
| Example Structure |  |
| Synonyms | ChGn-1, chondroitin beta-glucuronyltransferase, chondroitin glucuronyltransaferase II, chondroitin glucuronyltransferase, chondroitin glucuronyltransferase II, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucoronyltransferase, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glucuronyltransferase/chondroitin synthase-3, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase-3, ChSy, ChSy-1, ChSy-3, CHSY1, CHSY2, CHSY3, CSGalNAcT-1, CSGlcA-T, CSGlcAT, CSGlcAT-II, CSGlcAT/ChSy-3, CSS2, GlcAT-II, glucuronyltransferase, uridine diphosphoglucuronate-chondroitin, glucuronyltransferase-II, UDP-glucuronate:chondroitin glucuronyltransferase |
| EC Number | 2.4.1.226 |
| CAS Registry Number | 269077-98-7 |
| Comments | Involved in the biosynthesis of chondroitin and dermatan sulfate. The human chondroitin synthetase is a bifunctional glycosyltransferase, which has the 3-¦Â-glucuronosyltransferase and 4-¦Â-N-acetylgalactosaminyltransferase (EC 2.4.1.175) activities required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase ‘co-polymerases’ can be found in Pasteurella multocida and Escherichia coli. There is also another human protein with apparently only the 3-¦Â-glucuronosyltransferase activity. |
| Cofactor | |
| History | |
| Reactions | UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan = Udp + beta-D-glucuronosyl-(1->3)-N-acetyl- beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan. |
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