N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase EC#: 2.4.1.225; ChemWhat Code: 1377529
| Product Name | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase |
| Example Structure |  |
| Synonyms | diphosphoglucuronate:oligosaccharide uridine glucuronosyltransferase, exostosin, exostosin-1, exostosin-2, Exostosin1, Exostosin2, exotose-2, EXT-1, EXT-2, EXT-3, EXT1, EXT2, EXTL3, extosin, gene EXTL1 glycosyltransferase, gene EXTL2 glycosyltransferase, glucuronic acid/N-acetylglucosamine co-polymerase-1, glucuronosyltransferase, heparan glucuronosyltransferase II, heparan sulfate co-polymerase, heparan sulfate glucuronosyltransferase, heparan sulfate synthesis enzyme, N-acetylglucosaminylproteoglycan beta-1,4-glucuronosyltransferase, RIB-1, RIB-2, sister of tout velu, sister of tout-velu, sotv, tout velu, tout-velu, ttv, UDP-glucuronate:oligosaccharide |
| EC Number | 2.4.1.225 |
| CAS Registry Number | |
| Comments | Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-¦Á-N-acetylglucosaminyltransferase (EC 2.4.1.244) activity required for the synthesis of the heparan sulfate disaccharide repeats. |
| Cofactor | |
| History | |
| Reactions | UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan = Udp + beta-D-glucuronosyl-(1->4)-N-acetyl- alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan. |
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