N-acetyllactosaminide alpha-2,3-sialyltransferase EC#: 2.4.99.6; ChemWhat Code: 1377837
Product Name | N-acetyllactosaminide alpha-2,3-sialyltransferase |
Example Structure | |
Synonyms | alpha2,3(N) sialyltransferase, alpha2,3(N)ST, alpha2,3(O) sialyltransferase, alpha2,3(O)ST, alpha2–>3 sialyltransferase, CMP-NeuAc:Gal beta 1-4GlcNAc-R alpha(2-3)-sialyltransferase, cytidine monophosphoacetylneuraminate-beta-galactosyl(1–>4)acetylglucosaminide alpha2–>3-sialyltransferase, cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase, Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase, Galbeta(1->4)GlcNAc-R alpha(2->3)sialyltransferase, Galbeta1->4GlcNAc-R alpha2->3-sialyltransferase, GT-42 sialyltransferase, HAC1267, Hb-ST2, N-acetyllactosaminide alpha-2,3-sialyltransferase, PmST1, SAT-3, sialyltransferase, sialyltransferase 3, sialyltransferase, cytidine monophosphoacetylneuraminate-beta-galactosyl(1–>4)acetylglucosaminide alpha2–>3-, ST3Gal III, ST3Gal IV, ST3Gal VI, ST3Gal-III, ST3Gal-IV, ST3Gal3, St3gal6, ST3N |
EC Number | 2.4.99.6 |
CAS Registry Number | 77537-85-0 |
Comments | The enzyme recognizes the sequence ¦Â-D-galactosyl-(1¡ú4)-N-acetyl-D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1 [2]. |
Cofactor | |
History | |
Reactions | CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl-R = Cmp + N-acetyl-alpha-neuraminyl-(2->3)-beta-D- galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R. |
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