N-(long-chain-acyl)ethanolamine deacylase EC#: 3.5.1.60; ChemWhat Code: 1381255

Product Name N-(long-chain-acyl)ethanolamine deacylase
Example Structure Example Structure of N-(long-chain-acyl)ethanolamine deacylase EC#: 3.5.1.60
Synonyms amidase, acylethanolamine, N-acylethanolamine acid amidase, N-acylethanolamine amidohydrolase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, NAE-hydrolyzing acid amidase
EC Number 3.5.1.60
CAS Registry Number 99283-61-1
Comments This lysosomal enzyme acts best on palmitoyl ethanolamide, with lower activity on other?N-(long-chain-acyl)ethanolamines. It is only active at acidic pH. Unlike EC?3.5.1.99, fatty acid amide hydrolase, it does not act on primary amides such as oleamide, and has only a marginal activity with anandamide. The enzyme is translated as an inactive proenzyme, followed by autocatalytic cleavage into two subunits that reassociate to form an active heterodimeric complex.
Cofactor
History
Reactions N-(long-chain-acyl)ethanolamine + H(2)O = a long-chain carboxylate + ethanolamine.

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