N-terminal amino-acid Nalpha-acetyltransferase NatA EC#: 2.3.1.255; ChemWhat Code: 1377087

Product Name N-terminal amino-acid Nalpha-acetyltransferase NatA
Example Structure Example Structure of N-terminal amino-acid Nalpha-acetyltransferase NatA EC#: 2.3.1.255
Synonyms ARD homolog a, ARD1, ARD1-NAT1 Nalpha-acetyltransferase, ARD1131, ARD1198, ARD1225, ARD1235, ARD1p, arrest-defective protein 1, arrest-defective protein 1 homologue, DXS707, hNaa16p, hNat2, MUSE6, N-alpha-acetyltransferase 10, N-terminal protein acetyltransferase, NAA10, NAA10/ARD1, NAA15, Nalpha-acetyltransferase 10, NAT1, NatA, NatA acetyltransferase, NatA Nalpha-terminal acetyltransferase, NatA protein Nalpha-terminal-acetyltransferase complex, SSO0209, Ta0058, Ta1140, TE2, vnc
EC Number 2.3.1.255
CAS Registry Number
Comments N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free ¦Á-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine. Formerly EC 2.3.1.88.
Cofactor
History
Reactions (1) Acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-N(alpha)- acetyl-glycyl-[protein] + CoA. (2) Acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal- N(alpha)-acetyl-L-alanyl-[protein] + CoA. (3) Acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal- N(alpha)-acetyl-L-seryl-[protein] + CoA. (4) Acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal- N(alpha)-acetyl-L-valyl-[protein] + CoA. (5) Acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal- N(alpha)-acetyl-L-cysteinyl-[protein] + CoA.

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