| Product Name |
N-terminal L-serine Nalpha-acetyltransferase NatD |
| Example Structure |
 |
| Synonyms |
hNaa40p/hNatD, N(alpha)-acetyltransferase 40, N-alpha-acetyltransferase 40, Naa40, Naa40p, NAT4, NatD, Patt1 |
| EC Number |
2.3.1.257 |
| CAS Registry Number |
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| Comments |
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free ¦Á-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus. Formerly EC 2.3.1.88. |
| Cofactor |
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| History |
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| Reactions |
(1) Acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal- N(alpha)-acetyl-L-seryl-[histone H4] + CoA. (2) Acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal- N(alpha)-acetyl-L-seryl-[histone H2A] + CoA. |
