NADPH:quinone reductase EC#: 1.6.5.5; ChemWhat Code: 1374542
| Product Name | NADPH:quinone reductase |
| Example Structure |  |
| Synonyms | ArsH, Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate) (quinone), DT-diaphorase, EC 1.6.99.2, Flavoprotein NAD(P)H:quinone reductase, Menadione oxidoreductase, Menadione reductase, NAD(P)H dehydrogenase, NAD(P)H dehydrogenase (quinone), NAD(P)H menadione reductase, NAD(P)H quinone reductase, NAD(P)H-quinone dehydrogenase, NAD(P)H-quinone oxidoreductase, NAD(P)H-quinone reductase, NAD(P)H:(quinone-acceptor) oxidoreductase, NAD(P)H:menadione oxidoreductase, NAD(P)H:paraquat diaphorase, NADH-menadione reductase, NADH-menaquinone reductase, NADH:quinone reductase, NADPH DT-diaphorase, NADPH quinone acceptor oxidoreductase, NADPH-dependent quinone reductase, NADPH:azodicarbonyl/quinone reductase, NADPH:quinone oxidoreductase, NADPH:quinone reductase, Naphthoquinone reductase, NfsA, nitroreductase A, old yellow enzyme, p-Benzoquinone reductase, P1-ZCr, P1-zeta-crystallin, P36, Phylloquinone reductase, PtoQOR, QAO, Qor, QorA, Quinone reductase, Reduced NAD(P)H dehydrogenase, TcOYE, TmQR1, Viologen accepting pyridine nucleotide oxidoreductase, Vitamin K reductase, ZCr, zeta-Crystallin, zeta-crystallin homolog protein, zeta-crystallin/NADPH:quinone oxidoreductase, zeta-Crystallin/quinone reductase, Zta1, Zta1p |
| EC Number | 1.6.5.5 |
| CAS Registry Number | 9032-20-6 |
| Comments | a zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates [1]. Dicoumarol [cf. EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2 [1]. In some mammals the enzyme is abundant in the lens of the eye, where it is identified with the protein ¦Æ-crystallin. |
| Cofactor | Zn2+ |
| History | |
| Reactions | Nadph + 2 quinone = NADP(+) + 2 semiquinone. |
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