nardilysin EC#: 3.4.24.61; ChemWhat Code: 1381056
| Product Name | nardilysin |
| Example Structure |  |
| Synonyms | hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, NRDc |
| EC Number | 3.4.24.61 |
| CAS Registry Number | 157906-54-2 |
| Comments | Enzyme of 133 kDa from rat brain and testis. A homologue of pitrilysin containing the His-Phe-Leu-Glu-His zinc-binding sequence, and a highly acidic stretch of 71 residues. Unusually for a metalloendopeptidase, inhibited by bestatin, amastatin and?N-ethylmaleimide. In peptidase family?M16?(pitrilysin family). |
| Cofactor | Zn2+ |
| History | |
| Reactions | Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys. |
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