nebramycin 5′ synthase EC#: 6.1.2.2; ChemWhat Code: 1383587

Product Name nebramycin 5′ synthase
Example Structure Example Structure of nebramycin 5' synthase EC#: 6.1.2.2
Synonyms obramycin carbamoyltransferase, TacA, TobZ
EC Number 6.1.2.2
CAS Registry Number
Comments Requires Fe(III). The enzyme from the bacterium?Streptoalloteichus tenebrarius?catalyses the activation of carbamoyl phosphate to?O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin.
Cofactor Fe3+
History
Reactions (1) Tobramycin + carbamoyl phosphate + Atp + H(2)O = nebramycin 5′ + Amp + diphosphate + phosphate. (2) Kanamycin A + carbamoyl phosphate + atp + H(2)O = 6”-O- carbamoylkanamycin A + amp + diphosphate + phosphate.

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