nicotine blue oxidoreductase EC#: 1.1.1.328; ChemWhat Code: 1373442
Product Name
nicotine blue oxidoreductase
Example Structure
Synonyms
NAD(P)H-nicotine blue oxidoreductase, NAD(P)H-nicotine blue quinone oxidoreductase, nboR
EC Number
1.1.1.328
CAS Registry Number
Comments
The enzyme, characterized from the nicotine degrading bacterium Arthrobacter nicotinovorans, catalyses the reduction of ‘nicotine blue’ to its hydroquinone form (the opposite direction from that shown). Nicotine blue is the name given to the compound formed by the autocatalytic condensation of two molecules of 2,3,6-trihydroxypyridine, an intermediate in the nicotine degradation pathway. The main role of the enzyme may be to prevent the intracellular formation of nicotine blue semiquinone radicals, which by redox cycling would lead to the formation of toxic reactive oxygen species. The enzyme possesses a slight preference for NADH over NADPH.
