nocardicin A epimerase EC#: 5.1.1.14; ChemWhat Code: 1383049
Product Name
nocardicin A epimerase
Example Structure
Synonyms
Epimerase, isonocardicin A, nocardicin C-9’epimerase, NocJ
EC Number
5.1.1.14
CAS Registry Number
Comments
Requires pyridoxal 5′-phosphate. The enzyme, characterized from the bacterium?Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A. It catalyses the epimerization of the amino group at position 9′ from (S) configuration to (R). The enzyme can act on both isonocardicin A and isonocardicin C, but the?in vivo?substrate appears to be the latter [3].
Cofactor
pyridoxal 5′-phosphate
History
Reactions
(1) Isonocardicin C = nocardicin c. (2) Isonocardicin A = nocardicin a.
