non-specific polyamine oxidase EC#: 1.5.3.17; ChemWhat Code: 1374457
| Product Name | non-specific polyamine oxidase |
| Example Structure |  |
| Synonyms | AtPAO2, AtPAO3, AtPAO4, AtPAO5, Bjpao1, Bjpao2, Fms1, OsPAO1, PAO, PAO1, PAO2, PAO3, PAO5, polyamine oxidase 1, SelPAO5, T-Spm oxidase, thermospermine oxidase |
| EC Number | 1.5.3.17 |
| CAS Registry Number | |
| Comments | A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1]. The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase). |
| Cofactor | FAD |
| History | |
| Reactions | (1) Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2). (2) Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2). (3) N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2). (4) N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2). |
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