norspermine synthase EC#: 2.5.1.126; ChemWhat Code: 1378069
| Product Name | norspermine synthase |
| Example Structure |  |
| Synonyms | long-chain polyamine synthase, PaSpeE |
| EC Number | 2.5.1.126 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.127, caldopentamine synthase, this enzyme does not accept norspermine as a substrate. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl 3-(methylthio)propylamine + norspermidine = S-methyl- 5′-thioadenosine + norspermine. |
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