nuclear-inclusion-a endopeptidase EC#: 3.4.22.44; ChemWhat Code: 1380759
| Product Name | nuclear-inclusion-a endopeptidase |
| Example Structure |  |
| Synonyms | 49 kDa proteinase, 49 kDa-Pro, NIA, NIa protease, NIa protein, NIa proteins, NIa-Pro, nuclear inclusion a protease, nuclear inclusion a-protease, nuclear inclusion body protein a, nuclear inclusion protein A protease, nuclear inclusion protein-a protease, nuclear inclusion-a protease, potyvirus NIa protease, protease NIa, proteinase Nia, proteinase, polyprotein-processing, Nia, proteins (specific proteins and subclasses), NIa (nuclear inclusion, a), proteins NIa, proteins, small nuclear inclusion NIa, tobacco vein mottling virus protease |
| EC Number | 3.4.22.44 |
| CAS Registry Number | |
| Comments | The potyviruses cause diseases in plants, and inclusion bodies appear in the host cell nuclei; protein a of the inclusion bodies is the endopeptidase. The enzyme finds practical use when encoded in vectors for the artificial expression of recombinant fusion proteins, since it can confer on them the capacity for autolytic cleavage. It is also reported that transgenic plants expressing the enzyme are resistant to viral infection. Type example of peptidase family?C4. |
| Cofactor | |
| History | |
| Reactions | Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 – P1′ that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. |
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