Opine dehydrogenase EC#: 1.5.1.28; ChemWhat Code: 1374392
| Product Name | Opine dehydrogenase |
| Example Structure |  |
| Synonyms | Dehydrogenase, opine, N-(1-D-Carboxyethyl)-L-norvaline dehydrogenase, N-[1-(R)-(Carboxy)ethyl]-(S)-norvaline: NAD+ oxidoreductase (L-norvaline forming), ODH, OpDH |
| EC Number | 1.5.1.28 |
| CAS Registry Number | 108281-02-3 |
| Comments | in the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate. |
| Cofactor | |
| History | |
| Reactions | (2S)-2-((1-(R)-carboxyethyl)amino)pentanoate + NAD(+) + H(2)O = L-2- aminopentanoic acid + pyruvate + Nadh. |
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