oviductin EC#: 3.4.21.120; ChemWhat Code: 1380672
| Product Name | oviductin |
| Example Structure |  |
| Synonyms | alpha-fetoprotein, Gp43 processing protease, hAFP, hOV-1, oviductal protease, oviductin, oviductin-1, oviductin-I, ovochymase 2 |
| EC Number | 3.4.21.120 |
| CAS Registry Number | |
| Comments | The egg envelope of the South African clawed frog (Xenopus laevis) is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form. This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin. It is thought that the enzymatically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions [2]. The enzyme is also found in the Japanese toad (Bufo japonicus) [3]. Belongs in peptidase family?S1. |
| Cofactor | |
| History | |
| Reactions | Preferential cleavage at 371-Gly-Ser-Arg-|-Trp-374 of glycoprotein gp43 in Xenopus laevis coelemic egg envelope to yield gp41. |
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