p-cymene methyl-monooxygenase EC#: 1.14.15.25; ChemWhat Code: 1375716

Product Name p-cymene methyl-monooxygenase
Example Structure Example Structure of p-cymene methyl-monooxygenase EC#: 1.14.15.25
Synonyms cymA, cymAa, CymB, CymM, p-cymene methyl hydroxylase
EC Number 1.14.15.25
CAS Registry Number
Comments The enzyme, characterized from several Pseudomonas strains, initiates p-cymene catabolism through hydroxylation of the methyl group. The enzyme has a distinct preference for substrates containing at least an alkyl or heteroatom substituent at the para-position of toluene. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin¡ªNAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. In Pseudomonas chlororaphis the presence of a third component of unknown function greatly increases the activity. cf. EC 1.14.15.26, toluene methyl-monooxygenase.
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