p-cymene methyl-monooxygenase EC#: 1.14.15.25; ChemWhat Code: 1375716
| Product Name | p-cymene methyl-monooxygenase |
| Example Structure |  |
| Synonyms | cymA, cymAa, CymB, CymM, p-cymene methyl hydroxylase |
| EC Number | 1.14.15.25 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from several Pseudomonas strains, initiates p-cymene catabolism through hydroxylation of the methyl group. The enzyme has a distinct preference for substrates containing at least an alkyl or heteroatom substituent at the para-position of toluene. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin¡ªNAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. In Pseudomonas chlororaphis the presence of a third component of unknown function greatly increases the activity. cf. EC 1.14.15.26, toluene methyl-monooxygenase. |
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