| Product Name |
pentachlorophenol monooxygenase |
| Example Structure |
 |
| Synonyms |
dechlorinase, pentachlorophenol, oxygenase, pentachlorophenol 4-mono-, PCB hydroxylase, PCP hydroxylase, PCP-4-monooxygenase, PCP-monooxygenase, PCP4MO, PcpB, PcpD, pentachlorophenol 4-mono-oxygenase, pentachlorophenol 4-monooxygenase, pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol hydroxylase, pentachlorophenol monooxygenase, pentachlorophenol-4-monooxygenase, tetrachlorobenzoquinone reductase |
| EC Number |
1.14.13.50 |
| CAS Registry Number |
124148-88-5;136111-57-4 |
| Comments |
A flavoprotein (FAD). The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position [2]. If C-4 carries a halogen substituent, reaction 1 is catalysed; if C-4 is unsubstituted, reaction 2 is catalysed. |
| Cofactor |
FAD |
| History |
|
| Reactions |
(1) Pentachlorophenol + Nadph + O(2) = 2,3,5,6-tetrachloro-1,4- benzoquinone + NADP(+) + chloride + H(2)O. (2) 2,3,5,6-tetrachlorophenol + Nadph + O(2) = 2,3,5,6- tetrachlorohydroquinone + NADP(+) + H(2)O. |
