EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, pepsin, pepsin 1, pepsin A, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsins A1, pepsins A2, PG1, shewasin A
EC Number
3.4.23.1
CAS Registry Number
9001-75-6
Comments
The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis. Human pepsin A occurs in five molecular forms. Pig pepsin D [1,2] is unphosphorylated pepsin A. Type example of peptidase family?A1. Formerly EC?3.4.4.1.
Cofactor
History
Reactions
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1′ positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.
