phenylacetyl-CoA dehydrogenase EC#: 1.17.5.1; ChemWhat Code: 1376011
| Product Name | phenylacetyl-CoA dehydrogenase |
| Example Structure |  |
| Synonyms | More, oxidase, phenylacetyl coenzyme A (alpha-oxidizing), phenylacetyl-CoA alpha-carbon-oxidizing oxidase, phenylacetyl-CoA-acceptor oxidoreductase, phenylacetyl-CoA:acceptor oxidoreductase |
| EC Number | 1.17.5.1 |
| CAS Registry Number | |
| Comments | The enzyme from Thauera aromatica is a membrane-bound molybdenum¡ªiron¡ªsulfur protein. The enzyme is specific for phenylacetyl-CoA as substrate. Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates. The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen. Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone [1]. A second enzyme, EC 3.1.2.25, phenylglyoxylyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate. |
| Cofactor | iron-sulfur;Mo-molybdopterin |
| History | |
| Reactions | Phenylacetyl-CoA + H(2)O + 2 quinone = phenylglyoxylyl-CoA + 2 quinol. |
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