| Product Name |
phenylalanine/tyrosine ammonia-lyase |
| Example Structure |
 |
| Synonyms |
PAL, PAL/TAL, PAL4, phenylalanine-tyrosine ammonia lyase, PTAL, RtPAL, Sb04g026510, Sb06g022740, SbPAL1 |
| EC Number |
4.3.1.25 |
| CAS Registry Number |
|
| Comments |
This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC?4.3.1.3?(histidine ammonia-lyase), EC?4.3.1.23?(tyrosine ammonia-lyase) and EC?4.3.1.24?(phenylalanine ammonia-lyase). The enzyme from some monocots, including maize, and from the yeast?Rhodosporidium toruloides, deaminate?L-phenylalanine and?L-tyrosine with similar catalytic efficiency [3]. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [4]. |
| Cofactor |
MIO |
| History |
|
| Reactions |
(1) L-phenylalanine = trans-cinnamate + ammonia. (2) L-tyrosine = trans-p-hydroxycinnamate + ammonia. |
